Firstly, their modes of action differ slightly with maca having more of an effect solely on anandamide levels and less direct action on CB1 or CB2 receptors. This mode of increasing the concentration of human endocannabinoids, rather than administering exogenous plant cannabinoids, offers many therapeutic advantages and can reduce cannabinoid-like adverse events. Therefore, FAAH inhibitors like the macamides found in maca have the potential to provide a more natural way to return balance to the body. Their onset of action is mild and slow, however they act more accumulatively and sustainably for long-term consistent health benefits without losing sensitivity.
Like maca, not all cannabis is equal and there are some plant cannabinoids that also display similar properties. Cannabidiol (CBD) for example has been shown to be more selective for preventing anandamide re-uptake than interacting directly with the CB1 receptors. This mode of action works well in complement with maca and macamides. Reduced re-uptake of anandamide by CBD and reduced breakdown of anandamide by maca provide a powerful synergistic effect to bring about HPA regulation more rapidly than either plant independently. So combining them in treatment makes perfect sense. To see more about the benefits of maca review our article.
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By Dr Corin Storkey.Seleno Health. the Maca Specialists